Research articles showing how Testosterone and Estrogen (Estradiol) cause different brain chemistry/function between men and women.
Clinical research has demonstrated a significant sex difference in the
occurrence of depressive disorders. Beginning at pubertal onset, women
report a higher incidence of depression than men. Women are also
vulnerable to the development of depressive disorders such as
premenstrual dysphoric disorder, postpartum depression, and
perimenopausal depression. These disorders are associated with
reproductive stages involving changes in gonadal hormone levels.
Specifically, female depression and female affective behaviors are
influenced by estradiol levels.
Estrogenic mediati... [Prog Neuropsychopharmacol Biol Psychiatry. 2014] - PubMed - NCBI
The literature suggests that while there are many similarities in brain
structure, function, and neurotransmission in healthy men and women,
there are important differences that distinguish the male from the
female brain.
Evolving knowledge of sex differences in bra... [Biol Psychiatry. 2007] - PubMed - NCBI
Of particular interest are sex differences that have been identified in
the brain. Although the brains of men and women are highly similar, they
show consistent differences that have important implications for each
sex. That is,
brain sex differences uniquely affect biochemical
processes, may contribute to the susceptibility to specific diseases,
and may influence specific behaviors. Such biological differences should
never be used to justify discrimination or sexism. However, we believe
that a thorough understanding of these differences can inform
researchers and clinicians so that they can better address important
issues. Two examples include how genetic sex can lead to differences
between the sexes in the etiology and the progression of disease and how
differences in neural development may result in differences in
cognition and behavior.
The Genetics of Sex Differences in Brain and Behavior
"...sociologist J. Richard Urdy has found that females' responsiveness to encouragement of femininity is inversely related to their mothers'
testosterone levels during the second trimester of pregnancy.
"...
female rhesus money injected with androgens during the prenatal critical perioid later display stereotypic male sexual and nonsexual behavior. They engage in higher frequencies of threat behavior, play initiation, rough-and-tumble play, and chasing play...
a consistent relationship between hormones and behavior emerges that is not easy to dismiss by invoking different ad hoc criticisms of the individual findings.
Book: Biology at Work: Rethinking Sexual Equality
The incidence of psychopathy in the general population is generally considered to be 0·6-4% with a higher proportion of males to females. Brain imaging studies of psychopaths suggest a smaller and less active amygdala and prefrontal cortex. There also appear to be physiological derangements in psychopathy, including alterations/dysregulation in neurotransmitter homeostasis (dopamine and serotonin), altered endocrine responses
(testosterone and cortisol)
Psychopathy: clinical features, developmen... [J Clin Pharm Ther. 2014] - PubMed - NCBI
The recognition memory tasks, novel object and novel object location, have been beneficial to neuroendocrine research concerning the effects of gonadal and adrenal hormones on cognitive function...Experiments conducted across a number of laboratories show that
gonadal hormones, both estradiol and testosterone, promote memory while the adrenal hormone, corticosterone, impairs memory.
Department of Psychology, Hunter College of CUNY.
Recognition memory tasks in neuroendocrine r... [Behav Brain Res. 2014] - PubMed - NCBI
The gonadal steroids play an important role in altering the
survival or death of neurons within the brain as well regulating the
development of neuronal processes (such as the number and length of
dendrites and dendritic spines, or the degree of axonal branching).
I
n this regard, we can say that steroid hormones have
organizational effects that produce sex differences in the
connections and functions of the brain. Gonadal steroids also have
activational effects; these activational effects are transient
and are thought to coordinate behavior with either an internal event,
such as ovulation, or an external event, such as the presence of a
sexual partner.
Psychology Course
http://www.umich.edu/~psycours/531/becker.chapter3.htm
The specific
impact of sex hormones on brain
development and acoustic communication is known from animal models. Sex
steroid hormones secreted during early development play an essential
role in hemispheric organization and the functional lateralization of
the
brain, e.g. language. In animals, these hormones are well-known regulators of vocal motor behaviour.
Sex hormone influence on human infants' sound char... [Biol Lett. 2014] - PubMed - NCBI
Boys with higher levels of
prenatal testosterone
who were also exposed to higher levels of nicotine and alcohol during
pregnancy exhibited increased hyperactivity-impulsivity during early
childhood, but girls did not exhibit this same pattern. Thus, high
prenatal
testosterone
exposure seems to increase risk for DBD symptoms particularly in males
by increasing susceptibility to prenatal environmental stressors.
Prenatal testosterone increases sensiti... [Neurotoxicol Teratol. 2014] - PubMed - NCBI
Genistein is a phytoestrogen, particularly abundant in soybeans, that is able to bind
estrogen
receptors exerting both estrogenic and antiestrogenic activities.
Genistein is largely present in the human diet even during pregnancy.
Embryos and fetuses are therefore, commonly exposed to genistein during
the development and after birth. In the present study, we used a murine
model as a test end-point to investigate the effects of early exposure
to genistein on adult male
behavior
and related neural circuits. Exposure of dams to genistein (100μg/g of
body weight) daily during late pregnancy and early lactation, produced
in male offspring, when adults, significant changes in anxiety
behavior
and statistically significant variations in the number of neuronal
nitric-oxide synthase positive cells in the amygdala. In conclusions,
these data indicate that early exposure to phytoestrogens may induce
life-long effects on the differentiation of brain structures and
behaviors.
Perinatal exposure to genistein affects the no... [Physiol Behav. 2014] - PubMed - NCBI